The Role of Uncoupling Proteins in Diabetes Mellitus

Figure 3

The role of UCPs on the development of DM and/or complications. UCPs may affect the development of DM through 4 aspects: decrease mitochondrial membrane potential, increase energy expenditure especially through glucose and lipid metabolisms, downregulate ROS generation, and gene polymorphisms. The green arrows represent pathways activation, the dotted green arrow means that this pathway needs to be further proved, and the red inhibition arrows represent the inhibition effect.