Notch Signaling Molecules Activate TGF-β in Rat Mesangial Cells under High Glucose Conditions

Figure 1

The expression of Notch pathway components as measured by Western blotting following treatment of GMC with various glucose concentrations for 24 h. (a) Notch-associated molecule proteins at different glucose concentrations and high osmotic pressure at 24 h. Notch-associated molecules increased in the high glucose group; they had the most significant changes in the HG2 group, but there were no apparent differences between the NC group and the OP group. (b) The gray graph shows the relative statistical values of Notch-associated molecules for each group. The expression of the Notch-associated molecules increased in the high glucose group, especially, in the HG2 group. ^◊𝑃<0.05 versus OP group; ^▴𝑃<0.05 versus NC group, ^▪𝑃<0.05 versus HG group; *𝑃<0.05 versus HG2 group.

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