The GLP-1 Analogue Exenatide Improves Hepatic and Muscle Insulin Sensitivity in Diabetic Rats: Tracer Studies in the Basal State and during Hyperinsulinemic-Euglycemic Clamp

Figure 5

HGP and the disappearance rate of glucose (GR_d) during the hyperinsulinemic-euglycemic clamp steady state. HGP following an overnight fast was higher () in the D group rats than that in the D + E group rats. During clamp steady state, HGP was greater () in the D group rats than that in the D + E group rats (a). In the basal state, the D + E group rats had a lower GR_d than the D group rats (). The C + E group rats also had a lower GR_d than the C group rats, but this was not significantly different (b). Under the clamp steady state, the GR_d of the D group rats was lower than that of the C group rats () and that of the C + E group rats (). The GR_d of the D + E group rats was also significantly lower than that of the C group rats () and that of the C + E group rats (). There was no significant difference found between the C group rats and the C + E group rats () (b). , compared with basal. , compared with C group. , compared with C + E group. ^§,   compared with D group.

(a)

(b)