Alloxan-Induced Diabetes Causes Morphological and Ultrastructural Changes in Rat Liver that Resemble the Natural History of Chronic Fatty Liver Disease in Humans
Table 1
Medians, maximum, and minimum values of parameters related to liver function of nondiabetic control and untreated diabetic rats during the various experimental follow-up periods.
Groups
Follow-up
Parameters
Bilirubin
AST
ALT
Alkaline Ph
-GT
(mg/dL)
(U/L)
(U/L)
(U/L)
(U/L)
NC
2 weeks
0.42 (0.32–0.76)
30 (20–32)
36 (34–50)
68 (60–105)
84 (52–96)
UD
0.56 (0.38–0.80)
96* (35–115)
87* (42–108)
76 (66–102)
70 (58–105)
value
0.6870
<0.001
<0.001
0.3860
0.4254
NC
6 weeks
0.50 (0.30–0.80)
26.5 (18–36)
41.0 (35–52)
79.5 (65–102)
70.5 (46–112)
UD
0.54 (0.38–0.75)
29.0 (18–36)
92.0* (37–96)
85.0 (67–110)
80.5 (56–108)
value
0.9705
0.6305
<0.001
0.4813
0.3930
NC
14 weeks
0.60 (0.55–0.74)
26.5 (22–30)
39.0 (28–50)
55.0 (48–72)
31.0 (22–45)
UD
0.70 (0.56–0.80)
28.5 (26–32)
80.0* (66–97)
64.5 (50–80)
39.0 (32–50)
value
0.3429
0.3229
<0.001
0.3362
0.2702
NC
26 weeks
0.39 (0.28–0.52)
42.0 (38–50)
43.0 (26–55)
55.0 (36–80)
40.5 (22–54)
UD
0.44 (0.30–0.60)
51.5 (40–56)
78.5* (72–92)
67.5 (55–90)
53.0 (38–70)
value
0.4857
0.2000
<0.001
0.3429
0.2000
NC: nondiabetic control; UD: untreated diabetic; AST: aspartate aminotransferase; ALT: alanine aminotransferase; Alkaline Ph: alkaline phosphatase; γ-GT: gamma glutamil transferase. *NC < UD at 2, 6, 14, and 26 weeks of follow-up (Mann-Whitney test).
