Association of Plasma Adiponectin and Oxidized Low-Density Lipoprotein with Carotid Intima-Media Thickness in Diabetic Nephropathy
Table 1
Anthropometric, clinical, and biochemical characteristics of patients with type 2 diabetes in the absence or presence of nephropathy at different stages. Results for continuous variables are presented as mean (S.D.) or median (range).
Stage of diabetic nephropathy
Control
1 & 2
3 & 4
5
25
22
42
30
Age (y)
64.0 (7.1)
67.5 (8.8)
69.4 (8.2)
69.1 (9.7)
0.07
Gender (M/F)
8/17
3/13
25/17
13/17
0.14
BMI (kg/m2)
31.9 (6.6)
30.5 (4.1)
32.3 (4.8)
29.4 (5.2)
0.10
Duration of T2DM (y)
10.8 (5.8)
13.7 (7.0)
16.9 (9.0)
16.0 (6.6)
0.01
Fasting glucose (mg/dL)
151.8 (38.1)
148.8 (43.9)
159.0 (49.2)
189.4 (99.7)
0.07
HbA1c (%)
7.4 (1.0)
7.1 (0.8)
7.8 (1.4)
7.3 (0.9)
0.10
eGFR (mL/min/1.73 m2)
86.2 (14.3)
77.7 (12.7)
38.4 (11.2)
7.0 (3.0)
<0.001
Total cholesterol (mg/dL)
184.8 (51.6)
174.4 (37.5)
181.1 (43.8)
159.5 (47.7)
0.15
LDL-cholesterol (mg/dL)
101.3 (42.4)
98.1 (34.5)
101.0 (33.4)
87.0 (42.0)
0.41
HDL-cholesterol (mg/dL)
48.0 (11.3)
52.6 (16.5)
45.3 (10.2)
37.5 (9.6)
<0.001
Triglycerides (mg/dL)
115.0 (52–292)
139.5 (53–320)
170.0 (59–450)
170.5 (61–551)
0.006
Plasma adiponectin (μg/mL)
5.8 (2.2–12.4)
4.2 (2.4–36.5)
6.2 (2.0–38.8)
7.9 (3.2–43.2)
0.002
ox-LDL (U/L)
67.5 (21.5)
59.7 (17.3)
66.6 (17.4)
49.2 (16.3)
<0.001
Mean cIMT (mm)
0.81 (0.55–1.61)
0.86 (0.61–1.25)
0.92 (0.66–1.78)
0.93 (0.60–1.45)
0.022
Maximum cIMT (mm)
0.85 (0.60–1.65)
1.00 (0.65–1.30)
1.00 (0.70–1.80)
1.00 (0.65–1.50)
0.021
values of ANOVA or Kruskal-Wallis test for differences of variables among diabetic nephropathy stage groups.
