Exposure to Common Food Additive Carrageenan Alone Leads to Fasting Hyperglycemia and in Combination with High Fat Diet Exacerbates Glucose Intolerance and Hyperlipidemia without Effect on Weight

Figure 2

Hyperinsulinemic-euglycemic studies after 18 days of carrageenan exposure. (a) Blood glucose (mg/dL) was higher in the carrageenan-exposed mice than in the control mice at minutes. Elevation occurred when the glucose infusion rates were similar (see (b)) ( per group = 10). (b) Glucose infusion rate (mg/kg/minute) was significantly less in the carrageenan-exposed mice than in the control mice from 30 to 50 minutes, and the interval to achieve steady-state was prolonged by 30 minutes. (c) Endogenous was significantly less at baseline in the carrageenan-exposed mice than in the control mice. At steady-state, values were similar. (d) , rate of disappearance of glucose, was significantly less following carrageenan exposure at baseline, but similar at steady-state. (e) Serum insulin levels were similar before and after infusion (N.D. = no difference).

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