Use of Insulin and Mortality from Breast Cancer among Taiwanese Women with Diabetes
Table 2
Cox proportional hazards models showing mutually adjusted hazard ratios and their 95% confidence intervals for breast cancer mortality in women with diabetes.
Variables
Interpretation
Mutually adjusted hazard ratio
95% confidence interval
P value
Age
Every 1-year increase
1.027
(1.012, 1.042)
0.0005
Diabetes duration
Every 1-year increase
1.017
(0.995, 1.040)
0.1298
Diabetes type
Type 2 vs. Type 1
1.418
(0.527, 3.814)
0.4887
Body mass index
Every 1-kg/m2 increase
0.973
(0.933, 1.015)
0.2091
Smoking
Yes vs. No
1.000
(0.442, 2.261)
0.9995
Insulin use
Yes vs. No
1.339
(0.782, 2.293)
0.2878
Area of residence
Urban vs. Rural
1.294
(0.955, 1.752)
0.0958
Sensitivity analyses
Excluding patients who died of breast cancer within 3 years of diabetes onset
Age
Every 1-year increase
1.031
(1.016, 1.047)
<0.0001
Diabetes duration
Every 1-year increase
1.020
(0.998, 1.043)
0.0719
Diabetes type
Type 2 vs. Type 1
1.378
(0.513, 3.706)
0.5250
Body mass index
Every 1-kg/m2 increase
0.976
(0.935, 1.020)
0.2780
Smoking
Yes vs. No
1.047
(0.462, 2.370)
0.9126
Insulin use
Yes vs. No
1.384
(0.806, 2.375)
0.2387
Area of residence
Urban vs. Rural
1.333
(0.976, 1.819)
0.0705
Sensitivity analyses conducted after excluding patients who died of breast cancer within 5 years and 7 years of diabetes onset separately did not remarkably change the adjusted hazard ratios.
