Unique Aspects of Cryptochrome in Chronobiology and Metabolism, Pancreatic β-Cell Dysfunction, and Regeneration: Research into Cysteine414-Alanine Mutant CRY1

Table 1

Expression change in clock-related genes of isolated islets. The mice were kept in LD 14:10 as described [15]. The lighting period was 07:00–21:00, and islets were harvested during 11:00–13:00.

Gene name	⁢Fold change (Tg/wild-type)
Hif	Down	9.60
Per3	Down	9.48
Rorγ	Down	8.68
Bmal1	Up	5.90
Cry1 (endogenous)	Down	4.98
Dbp	Down	4.60
Fbxl21	Down	4.55
Tef	Down	4.52
Per2	Down	3.57
Per1	Down	2.47
Cry2	Down	2.33