Research Article
Combining Donor Characteristics with Immunohistological Data Improves the Prediction of Islet Isolation Success
Table 2
Comparison of donor characteristics for successful and failed islet isolations (
,
, and
).
| | | Successful isolations
() | Failed isolations
() | P value |
| | Gender (F/M) | 17/44 | 38/60 | 0.16 | | Age (years) | 47.7 ± 11.3 | 45.3 ± 13.1 | 0.36 | | BMI (kg/m2) | 27.5 ± 4.1 | 25.4 ± 4.4 | 0.0003 | | BMI (<25 kg/m2) | 15/61 | 56/98 | 0.00006 | | BSA (m2) | 2.06 ± 0.2 | 1.93 ± 0.2 | 0.0004 | | Cause of death (traumatic/nontraumatic) | 17/44 | 21/77 | 0.36 | | Cold ischemia time (>8 hours) | 6/61 | 29/98 | 0.004 | | Intensive care hospitalization (days) | 3.5 ± 2.7 | 4.5 ± 3.0 | 0.009 | | Hospitalization (>96 hours) | 16/61 | 45/98 | 0.01 | | Vasoactive drugs (>20 units) | 12/61 | 36/98 | 0.02 | | Amylase levels (>2x normal levels) | 3/47 | 10/76 | 0.24 | | Blood glucose level (mmol/L) | 7.7 ± 2.0 | 7.9 ± 2.0 | 0.56 | | Pancreas weight (g) | 143.8 ± 45.7 | 135.2 ± 42.5 | 0.32 | | Pancreas consistency (edema) | 0/61 | 10/98 | 0.01 | | Collagenase (Serva/VitaCyte) | 44/17 | 74/23 | 0.56 | | Digestion time (min) | 19.1 ± 6.7 | 24.1 ± 9.9 | 0.0013 | | Digestion (>20 min) | 25/61 | 62/98 | 0.006 |
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