|
| Author | Study | Year | Country/
Ethnicity | Sample | TNFA -308 polymorphism | Case group frequency | Control group frequency | value | Odds ratio
(in article) |
|
| Vendrell et al. [11] | A polymorphism in the promoter of the tumor necrosis factor-α gene (/308) is associated with coronary heart disease in type 2 diabetic patients | 2002 | Spain | | GG
GA + AA | 63 (59.4%)
43 (40.6%) | 159 (76.8%)
48 (23.2%) | | OR = 1.96 |
|
| Shiau et al. [13] | TNF-α polymorphisms and type 2 diabetes mellitus in Taiwanese patients | 2003 | Taiwan | | GG
GA
AA | 218 (84.82%)
35 (13.62%)
4 (1.56%) | 168 (89.84%)
16 (8.56%)
3 (1.60%) | | — |
|
| Buraczynska et al. [14] | Genetic determination of TNF and myeloperoxidase production in dialyzed patients with diabetic nephropathy | 2004 | Poland | | | | Healthy | Other nephropathy |
(case versus control – healthy) | — |
| TNF1/TNF1 (GG) | 22 (59.5%) | 86 (74.8%) | 40 (69%) |
| TNF1/TNF2 (GA) | 13 (35.1%) | 24 (20.9%) | 15 (25.8%) |
| TNF2/TNF2 (AA) | 2 (5.4%) | 5 (4.3%) | 3 (5.2%) |
|
| Bouhaha et al. [15] | Study of TNF-α -308G/A and IL6 -174G/C polymorphisms in type 2 diabetes and obesity risk in the Tunisian population | 2010 | Tunisia | | GG
GA
AA | 141 (72.3%)
51 (26.1%)
3 (1.6%) | 204 (68.2%)
89 (29.7%)
6 (2.1%) | = 0.34 | — |
|
| Guzmán-Flores et al. [16] | Tumor necrosis factor-alpha gene promoter -308G/A and -238G/A polymorphisms in Mexican patients with type 2 diabetes mellitus | 2011 | Mexico | | GG
GA
AA | 225 (86.9%)
31 (12.0%)
3 (1.1%) | 573 (88.8%)
69 (10.7%)
3 (0.5%) | = 0.558
(GG versus GA)
= 0.238
(GG versus AA) | OR = 1.14
(GG versus GA)
OR = 2.55
(GG versus AA) |
|
| Szabó and Acsády [17] | Tumor necrosis factor-α 308 GA polymorphism in Atherosclerotic patients | 2011 | Hungary | | | DM + AVE | DM + MI | | < 0.05
(control versus DM + MI)
< 0.005
(control versus DM + AVE) | OR = 6.71
(DM + MI)
OR = 5.87
(DM + AVE) |
| GG | 40 (61.6%) | 42 (64.6%) | 141 (76.7%) |
| GA | 20 (30.7%) | 17 (26.2%) | 40 (21.7%) |
| AA | 5 (7.7%) | 6 (9.2%) | 3 (1.6%) |
|
| Garg et al. [18] | Proinflammatory cytokine gene polymorphisms and threat for coronary heart disease in a North Indian Agrawal population | 2012 | Indian | | GG
GA
AA | 117 (85.4%)
20 (14.59%)
0 | 146 (78.9%)
38 (20.54%)
1 (0.54%) | = 0.27 | OR = 1.08
(GA/AA versus GG) |
|
| Saxena et al. [19] | Association of IL-6, TNF-α, and IL-10 gene polymorphisms with type 2 diabetes mellitus | 2013 | Indian | | GG
GA
AA | 173 (81.2%)
33 (15.5%)
7 (3.3%) | 111 (79.3%)
25 (17.9%)
4 (2.9%) | = 0.3766 | OR = 1.07
(allele G versus A) |
|
| Sefri et al. [20] | TNFA -308G>A polymorphism in Moroccan patients with type 2 diabetes mellitus: a case-control study and meta-analysis | 2014 | Morocco | | GG
GA
AA | 38 (12.38%)
154 (50.16%)
115 (37.56%) | 60 (24.59%)
133 (54.51%)
51 (20.90%) | = 0.000002
(allele G versus A) | OR = 1.79
(allele G versus A) |
|
| Dabhi and Mistry [21] | Oxidative stress and its association with TNF-α -308G/C and IL-1α -889C/T gene polymorphisms in patients with diabetes and diabetic nephropathy | 2015 | Indian | | GG
GA
AA | 185 (86.40%)
27 (12.62%)
2 (0.97%) | 191 (81.11%)
44 (18.88%)
0 | = 0.41 | OR = 0.75 |
|
