The Relation between Serum Uric Acid and HbA1c Is Dependent upon Hyperinsulinemia in Patients with Newly Diagnosed Type 2 Diabetes Mellitus
Table 3
Multiple linear regression for SUA, HbA1c, and InsAUC120.
Male
Female
Model 1: the dependent variable is HbA1c
Age (yr)
0.007
0.038
0.662
0.508
0.061
0.265
3.198
0.002
BMI (kg/m2)
0.028
0.045
0.752
0.452
0.133
0.190
2.302
0.023
SBP (mmHg)
−0.003
−0.027
−0.474
0.636
0.009
0.060
0.692
0.490
DBP (mmHg)
−0.012
−0.057
−1.01
0.314
−0.007
−0.038
−0.444
0.658
TG (mmol/L)
0.009
0.006
0.112
0.911
1.091
0.143
1.772
0.079
Cr (mol/L)
−0.014
−0.082
−1.524
0.128
−0.027
−0.114
−1.429
0.156
SUA (mol/L)
−0.001
−0.041
−0.710
0.478
−0.004
−0.109
−1.324
0.188
InsAUC120
−1.434
−0.456
−7.864
0.000
−1.573
−0.464
−5.465
0.000
Model 2: the dependent variable is SUA
Age (yr)
−1.753
−0.267
−5.470
0.000
0.152
0.022
0.262
0.793
BMI (kg/m2)
5.708
0.241
5.044
0.000
1.178
0.055
0.690
0.491
SBP (mmHg)
0.544
0.116
2.288
0.023
0.219
0.049
0.556
0.579
DBP (mmHg)
−0.515
−0.066
−1.311
0.190
0.058
0.010
0.110
0.912
HbA1c (%)
−3.868
−0.103
−2.355
0.019
−6.036
−0.209
−2.617
0.010
TG (mmol/L)
4.914
0.088
1.972
0.049
50.428
0.234
2.953
0.004
Cr (mol/L)
2.043
0.310
6.913
0.000
0.891
0.127
1.583
0.115
Model 3: the dependent variable is SUA
Age (yr)
−1.694
−0.257
−4.945
0.000
0.723
0.111
1.167
0.245
BMI (kg/m2)
3.136
0.135
2.419
0.016
0.608
0.031
0.329
0.743
SBP (mmHg)
0.592
0.131
2.434
0.015
0.105
0.025
0.260
0.795
DBP (mmHg)
−0.439
−0.057
−1.06
0.288
0.061
0.011
0.115
0.908
HbA1c (%)
−1.369
−0.037
−0.710
0.478
−3.751
−0.132
−1.324
0.188
TG (mmol/L)
2.839
0.051
1.049
0.295
21.665
0.100
1.117
0.266
Cr (mol/L)
1.787
0.277
5.643
0.000
0.835
0.126
1.421
0.158
InsAUC120
26.771
0.230
3.924
0.000
19.767
0.206
1.997
0.038
SBP: systolic pressure, DBP: diastolic pressure, HbA1c: glycosylated hemoglobin, TG: triglycerides, Cr: creatinine, SUA: serum uric acid, and InsAUC120: the area under the curve of insulin from 0 to 120 min. Both uric acid and HbA1c have a regressive relationship with InsAUC120 and some related influencing factors, regardless of gender. There is no regressive relationship between SUA and HbA1c after adjusting InsAUC120. denotes statistical significance.
