The Relation between Serum Uric Acid and HbA1c Is Dependent upon Hyperinsulinemia in Patients with Newly Diagnosed Type 2 Diabetes Mellitus
Table 4
Multiple linear regression for SUA and HbA1c in patients with high and low insulin levels.
Male
Female
High insulin levels: the dependent variable is SUA
Age (yr)
−2.062
−0.355
−4.346
0.000
1.224
0.181
1.324
0.191
BMI (kg/m2)
4.480
0.200
2.644
0.009
3.382
0.149
1.207
0.232
SBP (mmHg)
0.156
0.033
0.383
0.702
0.714
0.170
0.976
0.333
DBP (mmHg)
0.164
0.023
0.263
0.793
−0.601
−0.083
−0.474
0.637
HbA1c (%)
−4.923
−0.111
−1.582
0.016
−9.995
−0.329
−2.450
0.007
TG (mmol/L)
5.363
0.099
1.382
0.169
4.654
0.049
0.382
0.704
Cr (mol/L)
1.670
0.244
3.262
0.001
0.124
0.018
0.136
0.892
Low insulin levels: the dependent variable is SUA
Age (yr)
−0.973
−0.143
−1.858
0.065
0.577
0.097
0.631
0.531
BMI (kg/m2)
3.017
0.118
1.561
0.121
−0.138
−0.008
−0.055
0.956
SBP (mmHg)
0.792
0.201
2.520
0.013
−0.338
−0.086
−0.585
0.561
DBP (mmHg)
−1.276
−0.166
−2.152
0.033
0.345
0.078
0.587
0.560
HbA1c (%)
−2.850
−0.062
−1.202
0.131
0.230
0.008
0.056
0.956
TG (mmol/L)
0.372
0.007
0.096
0.924
12.483
0.156
1.108
0.273
Cr (mol/L)
1.974
0.352
4.782
0.000
1.400
0.226
1.723
0.090
Serum uric acid has an independent relationship with HbA1c through multiple stepwise regression analysis in patients with hyperinsulinemia, while there is no association between SUA and HbA1c in patients with hypoinsulinemia. denotes statistical significance.
