Topical Administration of Pirfenidone Increases Healing of Chronic Diabetic Foot Ulcers: A Randomized Crossover Study

Table 4

Adverse events.

	Group 1		Group 2
	Weeks 0 to 7	Weeks 8 to 16	Weeks 0 to 7	Weeks 8 to 16
	Pirfenidone	Conventional treatment	Conventional treatment	Pirfenidone
Osteomyelitis	4 (eliminated)	0	6 (eliminated)	0
Hypergranulation	0	0	0	1
Thyroid carcinoma	0	0	1 (eliminated)	0
Total AE	4	0	7	1