Inhibition of MEK1 Signaling Pathway in the Liver Ameliorates Insulin Resistance

Figure 2

Effects of RO5126766 on (a) food intake (FI), (b) body weight (BW), (c) blood glucose, (d) glucose excursion, and (e) AUC during the oral glucose tolerance test (OGTT) in db/db mice, with RO5126766 administered for 14 days as a dietary admixture with dosages as indicated: open circle, 0 mg in 1 kg CE-2; open square, 0.86 mg in 1 kg CE-2; closed circle, 1.72 mg in 1 kg CE-2; and closed triangle, 3.44 mg in 1 kg CE-2. Data are expressed as mean ± SEM, (control group, 0 mg in 1 kg CE-2) or 5. < 0.05, < 0.01, and < 0.001 versus control at the same measurement time by parametric Dunnett’s multiple comparison test.

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