Uninephrectomized High-Fat-Fed Nicotinamide-Streptozotocin-Induced Diabetic Rats: A Model for the Investigation of Diabetic Nephropathy in Type 2 Diabetes

Figure 11

Glomerulosclerotic lesions in experimental groups at week 30. (a) Kidney sections were stained with periodic acid-Schiff reagent (magnification ×400). Representative microphotographs from two groups of diabetic rats show appearance of focal mesangial lesion with an acellular hyaline cores indicated by black arrows. Moreover, white arrows show interstitial inflammatory infiltration. Glomerulus from low-dose streptozotocin-induced diabetic rat demonstrates partial mesangiolysis and appearance of “lobular” structure of glomerular tuft. (b) Graphic representation of semiquantitative indices of glomerulosclerosis in the studied groups. Mean values and standard deviations are shown.

(a)

(b)