Uninephrectomized High-Fat-Fed Nicotinamide-Streptozotocin-Induced Diabetic Rats: A Model for the Investigation of Diabetic Nephropathy in Type 2 Diabetes

Figure 7

Dynamics of renal tubular injury markers in control, NA-STZ, and LD-STZ groups throughout the experiment. (a) Changes in urinary excretion of NGAL (ng/24 h) measured at 10, 20, and 30 weeks of the experiment in the studied groups. (b) Changes in urinary excretion of KIM-1 (ng/24 h) measured at 10, 20, and 30 weeks of the experiment in the studied groups. Mean values and standard deviations are shown. ○ – , ○○ – in NA-STZ diabetic group versus control nondiabetic group at the same point of measurement. ● – , ●● – , and ●●● – in LD-STZ diabetic group versus control nondiabetic group at the same point of measurement. ■- in LD-STZ group versus NA-STZ group at the same point of measurement. compared to the first measurement in the same group at week 10.

(a)

(b)