Journal of Diabetes Research

Research Article

Uninephrectomized High-Fat-Fed Nicotinamide-Streptozotocin-Induced Diabetic Rats: A Model for the Investigation of Diabetic Nephropathy in Type 2 Diabetes

Table 1

Summary of metabolic parameters and serum levels of urea and creatinine in the control, NA-STZ, and LD-STZ groups measured at 10, 20, and 30 weeks of the experiment. Mean values and standard deviations are shown. versus NA-STZ: comparison of nicotinamide-streptozotocin-induced diabetic rats and the other two experimental groups at the same point of measurement. versus LD-STZ: comparison of low-dose-streptozotocin-induced diabetic rats and the other two experimental groups at the same point of measurement. N/A: not assayed.


Experimental groups	Control nondiabetic group			Low-dose streptozotocin-induced diabetic group			Nicotinamide-streptozotocin-induced diabetic group
Parameters Mean ± standard deviation	Week of the study			Week of the study			Week of the study
Parameters Mean ± standard deviation	10 weeks	20 weeks	30 weeks	10 weeks	20 weeks	30 weeks	10 weeks	20 weeks	30 weeks

HbA1 c, %	3.6	3.7	4.0	5.45	6.85	6.7	5.39	7.02	6.94
SD	0.29	0.13	0.26	0.61	0.21	0.43	0.34	0.29	0.27
versus NA-STZ	0.029	0.01	0.016	0.97	0.39	0.46
versus LD-STZ	0.028	0.029	0.028

Serum insulin level, pmol/L	83.5	96.6	87.8	50.2	54.0	59.6	49.6	51.3	50.9
SD	6.81	9.18	6.24	8.13	10.46	8.93	7.34	8.72	8.85
versus NA-STZ	0.028	0.009	0.015	0.88	0.76	0.27
versus LD-STZ	0.03	0.027	0.28

HOMA-IR	1.93	2.23	2.01	2.76	2.78	2.83	3.20	2.87	2.91
SD	0.29	0.14	0.22	0.92	0.93	0.87	0.39	0.22	0.70
versus NA-STZ	0.028	0.014	0.031	0.31	0.99	0.77
versus LD-STZ	0.11	0.48	0.06

Total cholesterol, mmol/L	1.55	1.58	1.63	2.83	2.71	2.42	2.89	2.76	2.74
SD	0.35	0.20	0.27	0.35	0.19	0.32	0.25	0.23	0.21
versus NA-STZ	0.028	0.014	0.002	0.88	0.74	0.11
versus LD-STZ	0.028	0.031	0.008

Triglycerides, mmol/L	0.57	0.56	0.70	1.13	1.04	0.86	1.05	0.90	0.89
SD	0.08	0.12	0.17	0.49	0.41	0.33	0.18	0.12	0.19
versus NA-STZ	0.028	0.01	0.029	1.0	0.91	0.98
versus LD-STZ	0.029	0.057	0.21

Serum urea, mmol/L	N/A	N/A	6.5	N/A	N/A	8.7	N/A	N/A	8.82
SD			0.89			1.18			1.03
versus NA-STZ			0.06			0.96
versus LD-STZ			0.012

Serum creatinine, μmol/L	33.5	35.8	41.9	41.3	44.8	61.5	38.3	47.0	69.0
SD	3.42	3.61	4.09	6.24	6.50	11.62	2.99	4.0	4.30
versus NA-STZ	0.14	0.004	0.002	0.65	0.80	0.31
versus LD-STZ	0.11	0.038	0.008