Journal of Diabetes Research

Research Article

Plasma C1q/TNF-Related Protein-3 (CTRP-3) and High-Mobility Group Box-1 (HMGB-1) Concentrations in Subjects with Prediabetes and Type 2 Diabetes

Table 2

Spearman and partial correlation analyses between variables and plasma CTRP-3 and HMGB-1.


	Plasma CTRP-3		Plasma CTRP-3 (age- and sex-adjusted)		Plasma HMGB-1		⁢Plasma HMGB-1 (age- and sex-adjusted)


Age (years)	−0.152	0.021			0.106	0.111
FPG (mmol/L)	−0.745	<0.001	−0.756	<0.001	0.615	<0.001	0.61	<0.001
INS	−0.635	<0.001	−0.626	<0.001	0.604	<0.001	0.529	<0.001
HOMA-IR	−0.763	<0.001	−0.756	<0.001	0.693	<0.001	0.689	<0.001
2 h PG (mmol/L)	−0.67	<0.001	−0.66	<0.001	0.61	<0.001	0.604	<0.001
HbA1c (%)	−0.806	<0.001	−0.802	<0.001	0.677	<0.001	0.674	<0.001
BMI (kg/m²)	−0.219	0.001	−0.202	0.002	0.216	0.001	0.203	0.002
WHR	−0.374	<0.001	−0.357	<0.001	0.255	<0.001	0.242	<0.001
SBP (mmHg)	−0.089	0.181	−0.085	0.202	0.129	0.052	0.124	0.062
DBP (mmHg)	−0.14	0.034	−0.127	0.054	0.124	0.061	0.087	0.108
TC (mmol/L)	−0.094	0.154	−0.095	0.156	0.033	0.624	0.032	0.145
TG (mmol/L)	−0.213	0.001	−0.188	0.004	0.163	0.014	0.145	0.029
LDL-C (mmol/L)	−0.152	0.021	−0.142	0.032	0.25	<0.001	0.243	<0.001
HDL-C (mmol/L)	0.369	<0.001	0.372	<0.001	−0.403	<0.001	−0.405	<0.001
ALT (U/L)	−0.02	0.769	−0.014	0.829	0.022	0.736	0.02	0.77
AST (U/L)	−0.07	0.292	−0.064	0.342	0.024	0.722	0.019	0.772
γ-GGT (U/L)	−0.124	0.032	−0.115	0.051	0.136	0.027	0.085	0.114
Cr	−0.056	0.4	−0.055	0.41	0.066	0.324	0.067	0.319
IL-6 (pg/mL)	−0.797	<0.001	−0.781	<0.001	0.696	<0.001	0.695	<0.001

Correlations between variables were analyzed by Spearman’s correlation test and age- and sex-adjusted partial correlation test. CTRP-3, C1q/TNF-related protein-3; HMGB-1, high-mobility group box-1; FPG, fasting plasma glucose; FINS, fasting serum insulin; HOMA-IR, homeostasis model assessment for insulin resistance; 2 h PG, 2 h postchallenge plasma glucose; HbA1c, hemoglobin A1c; BMI, body mass index; WHR, waist-to-hip ratio; SBP, systolic blood pressure; DBP, diastolic blood pressure; TC, total cholesterol; TG, triglyceride; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol; AST, aspartate transaminase; ALT, alanine transaminase; γ-GGT, gamma-glutamyl transpeptidase; IL-6, interleukin-6.