Effects of a Novel Glucokinase Activator, HMS5552, on Glucose Metabolism in a Rat Model of Type 2 Diabetes Mellitus

Table 1

Effects of HMS5552 on biochemical parameters.

Group	TC (mmol/L)	TG (mmol/L)	FINS (mU/L)	FG (pg/mL)
Control	4.16 ± 0.92	0.81 ± 0.38	5.33 ± 1.21	71.25 ± 17.85
Diabetic	12.09 ± 3.24	3.66 ± 1.60	44.42 ± 3.71	35.88 ± 4.76
HMS-L	11.04 ± 2.75	3.43 ± 1.62	28.40 ± 4.94	43.38 ± 18.74
HMS-H	10.70 ± 3.77	3.11 ± 1.14	18.74 ± 3.48	51.13 ± 4.69

Data are expressed as mean ± SD (); HMS-L group, low-dose (10 mg/kg) HMS5552-treated diabetic group; HMS-H group, high-dose (30 mg/kg) HMS5552-treated diabetic group; TC: total cholesterol; TG: triglyceride; FINS: fasting insulin; FG: fasting glucagon.
, , compared with control group.
, compared with diabetic group.
, compared with HMS-L group.