The CNDP1 (CTG)₅ Polymorphism Is Associated with Biopsy-Proven Diabetic Nephropathy, Time on Hemodialysis, and Diabetes Duration

Figure 3

The CNDP1 (CTG)₅ genotype distribution is changed with time on dialysis and diabetes duration. To assess if the frequencies change over time, the χ² test for trend (Cochran-Armitage test for trend) was carried out. (a) The frequency of the homozygous CNDP1 (CTG)₅ genotype (10 leucine) significantly increased with time on hemodialysis. ((b) and (c)) Although the observed frequency of the homozygous (b) CNDP1 (CTG)₅ genotype uniformly increased with diabetes duration, this trend did not reach statistical significance. Yet, if patients with a heterozygous (c) CNDP1 (CTG)₅ genotype (one 5 allele) were included as well, a significant trend towards high frequencies with increasing diabetes duration was found. N.S.: not significant.

(a)

(b)

(c)