Preserved Expression of Skin Neurotrophic Factors in Advanced Diabetic Neuropathy Does Not Lead to Neural Regeneration despite Pancreas and Kidney Transplantation
Table 1
Background demographic data and clinical variables.
Group HC: healthy control subjects
Group DM: type 1 diabetic subjects
Group Tx1: SPK recipients reexamined at 14–30 months
Tx2: SPK recipients at 8 years following transplantation
12
12
13
13
Age (years)
43 (28–56)
37 (32–55)
39 (30–57)
44 (33–59)
BMI (kg/m2)
26.5 (22–37)
26 (22–36)
22.8 (19–28)
24 (20–29)
Diabetes duration (years)
—
18 (4–36)
22 (16–39)
23 (19–50)
Insulin dose (IU/day)
—
48.5 (40–71)
—
—
Pretransplant insulin dose
—
—
32 (20–61)
35 (16–54)
HbA1c
mmol/mol %
36 (25–37) 5.4 (4.4-5.5)
57.5 (47–79) 7.4 (6.4–9.4)
40 (34–52)/40 (35–54) 5.8 (5.3–6.9)/5.8 (5.3–7.1)
37 (32–43) 5.5 (5.1–6.1)
Pretransplant HbA1c
mmol/mol %
—
—
74 (45–99) 8.9 (6.3–11.2)
63 (44–84) 7.9 (6.2–9.8)
Serum creatinine (μmol/l)
81.3 (59–112)
86.1 (56–101)
103 (62–186)/103.7 (81–154)
100 (75–121)
Data are given as medians and range (in parentheses). If not stated otherwise, the values were determined at the time of investigation.
