Association of EPHX2 R287Q Polymorphism with Diabetic Nephropathy in Chinese Type 2 Diabetic Patients

Table 4

Association of R287Q with risk of DN in different Hcy-level groups.

Hcy level (umol/L)		Unadjusted		Adjusted^a
	Genotype	OR (95% CI)		OR (95% CI)
Low: 4.29–10.78; ()	Additive	0.67 (0.44–1.02)	0.063	0.67 (0.41–1.10)	0.113
	Recessive	0.42 (0.14–1.27)	0.12	0.18 (0.03–0.98)	0.05
	Dominant	0.65 (0.38–1.11)	0.12	0.74 (0.40–1.38)	0.35
Medium:10.79–13.93; ()	Additive	0.74 (0.49–1.11)	0.14	0.81 (0.51–1.30)	0.38
	Recessive	0.22 (0.05–0.98)	0.047	0.27 (0.06–1.28)	0.10
	Dominant	0.82 (0.51–1.32)	0.41	0.93 (0.53–1.65)	0.81
High:13.94–55.99; ()	Additive	0.57 (0.38–0.84)	0.005	0.52 (0.33–0.81)	0.004
	Recessive	0.32 (0.13–0.82)	0.02	0.27 (0.09–0.78)	0.015
	Dominant	0.56 (0.34–0.92)	0.02	0.51 (0.29–0.90)	0.019

DN: diabetic nephropathy; Hcy: homocysteine. ^aAdjusted for age, sex, BMI, duration of diabetes, hypertension, smoking, total cholesterol, and TG levels.