Obesity-Linked Gut Microbiome Dysbiosis Associated with Derangements in Gut Permeability and Intestinal Cellular Homeostasis Independent of Diet

Figure 3

Lep^ob/ob mice exhibit significant gut microbiome dysbiosis compared to C57BL/6J (B6) mice fed with identical diet. (a) PCoA analysis shows differential clustering of the microbiome signature in Lep^ob/ob and B6 mice. (b, c) Microbial phylum abundance and Firmicutes : Bacteroidetes (F : B) ratio in Lep^ob/ob and B6 mice. (d–f) Significantly differing microbial families (d) and genera (e) abundances as well as fold change (percent) between Lep^ob/ob and B6 mice. Values presented here are average ± SEM/SD.

(a) PCoA

(b) Phylum

(c) Phylum abundance

(d) Family abundance

(e) Genera abundance

(f) % fold difference; Ob/Ob versus B6