Effect of Diacerein on Metabolic Control and Inflammatory Markers in Patients with Type 2 Diabetes Using Antidiabetic Agents: A Randomized Controlled Trial
Table 2
Mean values during the 12-week treatment and adjusted differences in mean changes between diacerein and placebo for the trial outcomes ().
Diacerein ()
Placebo ()
Adjusted difference in mean change (diacerein-placebo)
value
End of trial
Change from baseline
End of trial
Change from baseline
Metabolic profile
HbA1c (%)
8.1 ± 0.2
−0.98 ± 0.2
8.1 ± 0.2
−0.52 ± 0.2
−0.98 (−2.02 to 0.05)
0.06
HbA1c (mmol/mol)
65.9 ± 2.6
−10.8 ± 2.4
65.5 ± 2.6
−5.7 ± 2.3
−10.8 (−22.0 to 0.5)
0.06
Fasting glucose (mg/dL)
146.3 ± 13.1
4.3 ± 11.9
150.4 ± 12.9
11.8 ± 11.8
−19.8 (−78.3 to 38.5)
0.5
HOMA-IR
5.3 ± 0.8
−0.18 ± 0.7
6.2 ± 0.8
−0.27 ± 0.7
1.0 (−2.6 to 4.6)
0.6
Lipids
Total cholesterol (mg/dL)
148.7 ± 5.5
−0.3 ± 4.6
151.1 ± 5.2
−1.6 ± 4.5
−0.12 (−22.9 to 22.6)
1.0
HDLc (mg/dL)
41.3 ± 1.3
−0.8 ± 0.9
42.8 ± 6.9
−0.03 ± 0.8
−2.2 (−6.4 to 2.1)
0.3
LDLc (mg/dL)
79.9 ± 5.1
6.8 ± 6.1
78.2 ± 5.0
−3.2 ± 6.0
20.1 (−10.4 to 50.5)
0.19
Triglycerides (mg/dL)
153.1 ± 17.7
−47.4 ± 23.2
164.7 ± 17.4
−37.7 ± 22.9
−78.7 (−193.4 to 36.1)
0.18
Renal
Creatinine (mg/dL)
1.0 ± 0.04
0.06 ± 0.03
1.0 ± 0.04
0.03 ± 0.03
0.12 (−0.03 to 0.26)
0.11
eGFR (mL/min/1.73 m2)
73.9 ± 3.2
−3.1 ± 1.9
81.7 ± 3.2
−1.8 ± 1.9
−7.7 (−17.3 to 1.9)
0.12
Urinary albumin/creatinine ratio (mg/24 h)
24.0 ± 5.6
14.1 ± 5.2
27.3 ± 5.5
16.5 ± 5.2
6.0 (−19.4 to 31.4)
0.6
Hepatic
ALT (units/L)
24.4 ± 2.4
0.9 ± 1.6
25.1 ± 2.4
2.0 ± 1.5
0.5 (−6.5 to 7.5)
0.8
AST (units/L)
27.1 ± 2.3
2.4 ± 1.5
26.2 ± 2.3
4.3 ± 1.5
−0.6 (−8.0 to 6.8)
0.9
Gamma-glutamyltransferase (units/L)
44.9 ± 4.9
1.5 ± 2.4
39.3 ± 4.8
3.2 ± 2.3
−7.7 (−19.3 to 4.0)
0.19
Hematologic/inflammatory
Hematocrit (%)
42.7 ± 0.8
0.8 ± 0.8
43.4 ± 0.8
1.7 ± 0.8
0.5 (−3.6 to 4.5)
0.8
Platelet count (×109 cells/L)
230 ± 10.2
15.03 ± 7.3
236 ± 10.0
14.6 ± 7.2
−5.1 (−41.6 to 31.4)
0.8
C-reactive protein (mg/L)
9.0 ± 2.5
2.0 ± 3.3
12.3 ± 2.5
3.3 ± 3.2
−9.8 (−25.3 to 5.7)
0.2
Anthropometric assessment
Weight (kg)
77.6 ± 2.6
−2.7 ± 0.7
77.3 ± 2.6
−1.4 ± 0.7
−2.4 (−5.6 to 0.9)
0.16
Body mass index (kg/m2)
29.8 ± 1.0
−1.0 ± 0.2
30.8 ± 1.0
−0.6 ± 0.2
−0.8 (−2.0 to 0.4)
0.19
Mean adjusted for age, gender, duration of diabetes, and addition of new antidiabetic drugs.
