A Mouse Model of Beta-Cell Dysfunction as Seen in Human Type 2 Diabetes

Table 1

Insulin sensitivity, estimated using QUICKI, in low and high fat-fed mice treated with three consecutive once-daily doses of vehicle, or 30, 50, or 75 mg/kg STZ.

Diet	Treatment	n	QUICKI
Low fat	Vehicle	4	0.331 ± 0.010
	30 mg/kg STZ	4	0.318 ± 0.021
	50 mg/kg STZ	3	0.301 ± 0.030
High fat	Vehicle	4	0.256 ± 0.007
	30 mg/kg STZ	3	0.274 ± 0.009
	50 mg/kg STZ	6	0.292 ± 0.008
	75 mg/kg STZ	3	0.295 ± 0.016

, where is fasting insulin and is fasting glucose. Data are . versus low-fat vehicle.