Two-Year Changes in Hyperuricemia and Risk of Diabetes: A Five-Year Prospective Cohort Study

Table 2

The association between changes of hyperuricemia and incident diabetes.

Changes of hyperuricemia	Total	Diabetes (, %)	RR (95% CI)
			Model 1	Model 2^†	Model 3^‡
No hyperuricemia	11896	467 (3.93)	1.00	1.00	1.00
Remittent hyperuricemia	1286	115 (8.94)	1.87 (1.53-2.29)	1.54 (1.26-1.89)	1.35 (1.10-1.64)
Incident hyperuricemia	875	78 (8.91)	1.98 (1.56-2.51)	1.65 (1.30-2.09)	1.48 (1.17-1.86)
Persistent hyperuricemia	1346	181 (13.45)	2.62 (2.20-3.12)	2.05 (1.71-2.46)	1.75 (1.47-2.08)

Data were relative risks (RRs) and 95% confidence intervals (CIs). Hyperuricemia was defined as serum uric acid level greater than 7 mg/dL in males and serum uric acid level greater than 6 mg/dL in females. Adjusted for age and sex at baseline. ^†Adjusted for variables in model 1 as well as education level, smoking, alcohol consumption, physical activity, family history of diabetes, and body mass index at baseline. ^‡Adjusted for variables in model 2 as well as systolic blood pressure, diastolic blood pressure, total cholesterol, triglycerides, and high-density lipoprotein cholesterol at baseline.