Low Birth Weight, Cumulative Obesity Dose, and the Risk of Incident Type 2 Diabetes
Table 3
Adjusted hazard ratios (AHRs) of developing diabetes using multivariate Cox regression analyses.
Characteristic
Model number 0
Model number 1
Model number 2
Model number 3
AHR (95% CI)
value
AHR (95% CI)
value
AHR (95% CI)
value
AHR (95% CI)
value
Sex
Males versus females
1.328 (1.072, 1.646)
0.0095
1.483 (1.192, 1.843)
0.0004
1.297 (1.046, 1.608)
0.0177
1.329 (1.072, 1.647)
0.0094
Birth weight
Low birth weight versus normal
1.444 (0.966, 2.158)
0.0732
1.686 (1.125, 2.526)
0.0113
1.511 (1.010, 2.260)
0.0444
1.522 (1.017, 2.277)
0.0410
High birth weight versus normal
1.101 (0.774, 1.567)
0.5920
0.922 (0.647, 1.315)
0.6548
1.013 (0.712, 1.442)
0.9422
1.024 (0.719, 1.459)
0.8947
Cumulative obesity dose
1.080 (1.071, 1.088)
<0.0001
Time-varying BMI
1.098 (1.080, 1.117)
<0.0001
Last BMI
1.146 (1.084, 1.212)
<0.0001
Model evaluation
AIC
5940.762
5716.317
5851.199
5922.872
BIC
5952.257
5731.645
5866.526
5938.200
Model number 1 included sex, birth weight, and cumulative obesity dose as covariates; model number 2 includes sex, birth weight, and time-varying BMI as covariates; model number 3 includes sex, birth weight, and last BMI as covariates.
