Low Birth Weight, Cumulative Obesity Dose, and the Risk of Incident Type 2 Diabetes

Table 4

Adjusted hazard ratios (AHRs) of developing diabetes using multivariate Cox regression analyses: participants with the overweight/obesity onset during follow-up.

Characteristic	Model number 1		Model number 2		Model number 3
	AHR (95% CI)	value	AHR (95% CI)	value	AHR (95% CI)	value
Sex
Males versus females	1.544 (1.211, 1.968)	0.0004	1.399 (1.101, 1.777)	0.0060	1.405 (1.106, 1.784)	0.0053
Birth weight
Low birth weight versus normal	1.783 (1.137, 2.798)	0.0118	1.593 (1.017, 2.493)	0.0418	1.565 (1.000, 2.450)	0.0410
High birth weight versus normal	0.946 (0.651, 1.375)	0.7713	1.028 (0.708, 1.491)	0.8853	1.060 (0.731, 1.537)	0.8947
Age of obesity onset	0.988 (0.977, 1.000)	0.0434	0.976 (0.965, 0.986)	<0.0001	0.973 (0.962, 0.983)	<0.0001
Cumulative obesity dose	1.072 (1.062, 1.081)	<0.0001
Time-varying BMI			1.080 (1.059, 1.101)	<0.0001
Last BMI					1.044 (1.022, 1.066)	<0.0001
Model comparison
Model with age of obesity onset
AIC	4473.633		4605.563		4639.406
BIC	4491.824		4623.772		4657.616
Model without age of obesity onset
AIC	4475.874		4625.230		4666.389
BIC	4490.427		4639.798		4680.957