Protective Effect of the HIF-1A Pro582Ser Polymorphism on Severe Diabetic Retinopathy
Table 1
Characteristics of the patients.
Patients with no DR ()
Patients with mild-moderate NPDR ()
Patients with severe NPDR/PDR ()
value
Women/men ()
68/80
156/217
81/101
0.65
Ethnic origin, Caucasian vs. other (), (%)
145 (98.0)
370 (99.2)
179 (98.3)
0.47
Age (years)
(19-86)
(20-86)
(25-86)
<0.001
BMI (kg/m2)
(15.5-40.0)
(16.4-45.3)
(18.3-42.5)
0.55
Diabetes duration (years)
(3-66)
(8-73)
(12-69)
<0.001
HbA1c (%)
(5.5-12.5)
(5.6-12.1)
(4.7-12.7)
<0.001
HbA1c (mmol/mol)
(37-113)
(38-109)
(28-115)
e-GFR (mL/min/1.73 m2)
(23.6-133)
(18-140)
(7.2-140)
<0.001
TG (mmol/L)
(0.18-7.7)
(0.2-5.5)
(0.3-6.7)
<0.001
Cholesterol (mmol/L)
(2.7-8.4)
(2.0-7.7)
(2.6-8)
0.45
LDL (mmol/L)
(1.1-5.2)
(1.1-5.4)
(1.0-5.8)
0.38
HDL (mmol/L)
(0.8-3.8)
(0.6-4.2)
(0.5-3.7)
0.032
Systolic blood pressure (mmHg)
(90-170)
(85-180)
(90-180)
<0.001
Diastolic blood pressure (mmHg)
(50-95)
(40-100)
(40-100)
0.083
Data are presented as (range). The differences between the three groups were tested using the Kruskal-Wallis test. DR, diabetic retinopathy; NPDR, nonproliferative diabetic retinopathy; PDR, proliferative diabetic retinopathy; BMI, body mass index; HbA1c, glycated hemoglobin; e-GFR, estimated glomerular filtration rate; TG, triglycerides; LDL, low-density lipoprotein; HDL, high-density lipoprotein.
