Protective Effect of the HIF-1A Pro582Ser Polymorphism on Severe Diabetic Retinopathy
Table 3
Association in patients with type 1 diabetes between various demographic and disease factors and risk for severe NPDR/PDR (comparing no retinopathy () vs. severe NPDR/PDR ()).
Univariate logistic regression analysis
OR (95% CI)
value
Age
1.03 (1.02-1.05)
<0.0001
415
Sex (female vs. male)
0.96 (0.65-1.41)
0.821
415
Systolic blood pressure
1.03 (1.02-1.04)
<0.0001
414
Diastolic blood pressure
0.99 (0.97-1.01)
0.425
414
Duration
1.11 (1.09-1.13)
<0.0001
415
BMI (kg/m2)
1.01 (0.96-1.06)
0.616
414
HbA1c
1.06 (1.04-1.08)
<0.0001
415
Smoking ()
1.26 (0.70-2.27)
0.438
415
TG
1.79 (1.24-2.59)
0.002
415
HDL
0.68 (0.47-0.99)
0.046
414
LDL
0.99 (0.78-1.25)
0.929
412
Cholesterol
1.00 (0.82-1.23)
0.977
415
HIF-1A
330
CC
REF
CT
0.59 (0.30-1.16)
0.13
TT
0.16 (0.03-0.76)
0.02
Multivariate logistic regression analysis
OR (95% CI)
value
Duration
1.11 (1.09-1.15)
<0.0001
328
HbA1c
1.08 (1.06-1.11)
<0.0001
328
Systolic blood pressure
1.03 (1.01-1.05)
0.01
328
HDL
0.60 (0.34-1.07)
0.08
328
HIF1A
328
CC
REF
CT
0.79 (0.30-2.05)
0.62
TT
0.05 (0.003-0.91)
0.04
Univariate and multivariate logistic regression analyses were performed. BMI, body mass index; HbA1c, glycated hemoglobin; TG, triglycerides. CC, CT, and TT are the genotypes of the HIF-1A Pro582Ser polymorphism; REF, reference group.
