Different Contributions of Dyslipidemia and Obesity to the Natural History of Type 2 Diabetes: 3-Year Cohort Study in China
Table 2
Baseline factors associated with progression to prediabetes and diabetes.
Variables
NGT to pre-DM
NGT to DM
Pre-DM to DM
OR (95% CI)
value
OR (95% CI)
value
OR (95% CI)
value
Female
1.10 (0.90–1.36)
0.353
0.65 (0.45–0.93)
0.017
0.97 (0.73–1.30)
0.847
Age (years)
0.232
0.368
0.363
<50
1
1
1
50–60
1.19 (0.97–1.46)
0.090
1.22 (0.83–1.80)
0.304
1.03 (0.73–1.45)
0.872
≥60
1.09 (0.86–1.38)
0.485
1.36 (0.89–2.08)
0.151
1.24 (0.87–1.77)
0.235
BMI (kg/m2)
0.011
0.195
0.890
<24
1
1
1
24–28
1.18 (0.97–1.44)
0.093
1.20 (0.84–1.72)
0.317
1.04 (0.77–1.41)
0.793
≥28
1.45 (1.14–1.85)
0.003
1.51 (0·97–2.35)
0.072
1.09 (0.77–1.53)
0.629
TC (mmol/L)
<0.001
0.045
0.601
<5.18
1
1
1
5.18–6.19
1.50 (1.24–1.83)
<0.001
1.25 (0.87–1.80)
0.221
1.15 (0.85–1.54)
0.369
≥6.19
1.50 (1.15–1.97)
0.003
1.66 (1.05–2.61)
0.029
0.99 (0.70–1.39)
0.943
TG (mmol/L)
0.071
0.015
0.046
<1.70
1
1
1
1.70–2.25
1.14 (0.85–1.53)
0.388
1.38 (0.84–2.26)
0.203
0.94 (0.62–1.40)
0.745
≥2.25
1.40 (1.04–1.87)
0.025
1.97 (1.23–3.16)
0.005
1.36 (1.13–1.87)
0.024
mmHg
1.26 (1.05–1.51)
0.013
1.91 (1.39–2.64)
<0.001
1.33 (1.03–1.75)
0.029
Positive FHD
1.16 (0.59–2.30)
0.666
0.78 (0.18–3.41)
0.741
0.43 (0.14–1.30)
0.136
Drinking
1.04 (0.82–1.31)
0.776
0.99 (0.65–1.50)
0.956
0.79 (0.55–1.11)
0.175
Smoking
1.04 (0.78–1.39)
0.807
1.18 (0.73–1.90)
0.503
1.43 (0.95–2.15)
0.089
Physical inactive
1.04 (0.88–1.24)
0.639
1.16 (0.84–1.59)
0.366
1.12 (0.86–1.45)
0.410
FPG (mmol/L)
1.62 (1.28–2.06)
<0.001
1.78 (1.13–2.76)
0.012
—
—
Categories of pre-DM
0.009
i-IGT
—
—
—
—
1
i-IFG
—
—
—
—
1.41 (1.05–1.90)
0.022
IFG-IGT
—
—
—
—
1.63 (1.17–2.29)
0.004
Included in the model as a continuous variable. OR (95% CI): odds ratios and 95% confidence intervals calculated in the multivariate logistic model. Variables in the model: sex, age, family history of diabetes, smoking, drinking, physical inactive, SBP, BMI, TC, TG, FPG (for individuals with NGT at Baseline), or categories of pre-DM (for individuals with pre-DM at Baseline). NGT: normal glucose tolerance; Pre-DM: prediabetes; DM: diabetes mellitus; BMI: body mass index; TC: total cholesterol; TG: triglyceride; SBP: systolic blood pressure; FHD: family history of diabetes; FPG: fasting plasma glucose; i-IGT: isolated impaired glucose tolerance; i-IFG: isolated impaired fasting glucose; IFG-IGT: combined status of IFG and IGT.
