Hyperinsulinemia Can Cause Kidney Disease in the IGT Stage of OLETF Rats via the INS/IRS-1/PI3-K/Akt Signaling Pathway

<div>Changes of the mRNA and the protein level of IRS-1/PI3-K/Akt after being treated by different concentrations of insulin. (a) The mRNA level of IRS-1, PI3-K, and Akt of NRK-52E cells in indicated concentrations of insulin. (b) The expression of IRS-1, PI3-K, and Akt in indicated concentrations of insulin.</div>

Journal of Diabetes Research

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Figure 9

Figure 9: Hyperinsulinemia Can Cause Kidney Disease in the IGT Stage of OLETF Rats via the INS/IRS-1/PI3-K/Akt Signaling Pathway 