Research Article

HNF1α Controls Liver Lipid Metabolism and Insulin Resistance via Negatively Regulating the SOCS-3-STAT3 Signaling Pathway

Figure 1

Decreased HNF1α expression in FFA-induced fatty degeneration of LO2 cells. (a) Oil Red O staining showed that the number of lipid droplets in LO2 cells increased gradually with increased FFA induction time. (b) Biochemical indicators showed that with increasing FFA induction time, TC, TG, and NEFA content in the LO2 cells increased gradually. Reported values are the of the three independent tests, with , , and . (c, d) RT-qPCR, western blot, and immunofluorescence staining showed that the expression of HNF1a mRNA and protein decreased with increasing FFA induction time.
(a)
(b)
(c)
(d)