VDR Variants rather than Early Pregnancy Vitamin D Concentrations Are Associated with the Risk of Gestational Diabetes: The Ma’anshan Birth Cohort (MABC) Study
Table 3
The association between SNPs in vitamin D metabolism genes and the risk of GDM.
SNPs
Gene
Controls/cases
Vitamin D
†
Crude OR (95% CI)
Adjusted OR (95% CI)
rs1544410
VDR
0.021
0.067
CC
353/240
1.00
1.00
CT
27/34
1.85 (1.09-3.15)
2.03 (1.17-3.51)
rs731236
VDR
0.006
0.059
AA
341/237
1.00
1.00
GA
18/29
2.32 (1.26-4.28)
2.42 (1.29-4.55)
rs7041
GC
0.226
0.063
AA
170/107
1.00
1.00
CA
158/133
1.34 (0.96-1.87)
1.34 (0.94-1.90)
CC
24/19
1.26 (0.66-2.41)
1.28 (0.65-2.52)
rs2282679
GC
0.890
0.002
TT
167/127
1.00
1.00
GT
164/116
0.93 (0.67-1.30)
0.89 (0.63-1.25)
GG
32/25
1.03 (0.58-1.82)
1.06 (0.59-1.91)
rs3829251
DHCR7
0.834
0.399
GG
157/106
1.00
1.00
GA
179/132
1.09 (0.78-1.53)
1.06 (0.75-1.51)
AA
23/18
1.16 (0.60-2.25)
1.23 (0.61-2.46)
rs6013897
CYP24A1
0.306
0.462
TT
268/193
1.00
1.00
AT
105/69
0.91 (0.64-1.30)
0.91 (0.63-1.32)
AA
6/9
2.08 (0.73-5.95)
2.25 (0.76-6.65)
rs6599638
C10orf88
0.409
0.020
GG
87/65
1.00
1.00
GA
179/147
1.10 (0.75-1.62)
1.07 (0.71-1.60)
AA
88/55
0.84 (0.53-1.33)
0.79 (0.49-1.28)
Adjusted OR is adjusted for age, prepregnancy BMI, family history of diabetes, parity, smoking, drinking, income, education, and conception season. Abbreviations: BMI: body mass index; OR: odds ratio; CI: confidence interval. for the chi-square test. † for Student’s -test/ANOVA
