Journal of Diabetes Research

Research Article

The Effect of Lipotoxicity on Renal Dysfunction in a Nonobese Rat Model of Metabolic Syndrome: A Urinary Proteomic Approach

Table 1

Basal metabolic characteristics of Wistar () and HHTg rats () observed over the course of aging at 3, 12, and 20 months of age.
WistarHHTg1 value2 value
3 m12 m20 m3 m12 m20 m
Body weightn.s.
Adiposity index
Perirenal adipose tissue
Nonfasting glucose
Insulin







n.s.
AUC0-120
Serum triglycerides
Serum cholesteroln.s.
HDL-C
NEFA
Hepatic triglycerides







Values are given as , for each group; denotes , denotes , and denotes . Body weight (g), adiposity index (mg/g), perirenal adipose tissue (mg/g), glucose, triglycerides, cholesterol, AUC0-120 (mmol/l), HDL-C and NEFA (mmol/l), hepatic triglycerides (μmol/g), insulin (nmol/l).1 value: probability reflecting the effect of the strain. The analysis was performed using BMDP statistical software by two-way ANOVA and by the Bonferroni post hoc test for multiple comparisons.2 value: probability reflecting the combined effect of the strain and ageing. The analysis was performed using BMDP statistical software by two-way ANOVA and by the Bonferroni post hoc test for multiple comparisons.