The Effect of Lipotoxicity on Renal Dysfunction in a Nonobese Rat Model of Metabolic Syndrome: A Urinary Proteomic Approach

Table 4

Urinary proteomic biomarkers in Wistar () and HHTg rats () observed at 3 months of age before microalbuminuria onset and after microalbuminuria manifestation at 20 months of age.

	3 m		3 m value	20 m		20 m value	W/HHTg value
	W	HHTg		W	HHTg
Malondialdehyde (ng/ml)			n.s.			n.s.
8-Isoprostan (pg/ml)			n.s.			n.s.	n.s.
4-Hydroxynonenal (ng/ml)						n.s.
IL-6 (pg/ml)
IL-8 (pg/ml)
MCP-1 (ng/ml)
EGF (ng/ml)
α1-Antitrypsin (ng/ml)
Heparan sulfate (μg/ml)

Values are given as ; for each group; denotes , denotes , and denotes ._3 m: probability reflecting the effect of the strain at 3 months of age and were analysed by two-way ANOVA and by the Bonferroni post hoc test._20 m: probability reflecting the effect of the strain at 20 months of age and were analysed by two-way ANOVA and by the Bonferroni post hoc test._W/HHTg: probability reflecting the effect of the strain and were analysed by two-way ANOVA and by the Bonferroni post hoc test. IL-6: interleukin 6, IL-8: interleukin 8, MCP-1: monocyte chemoattractant protein-1, EGF: epidermal growth factor.