Association of Tumor Necrosis Factor Alpha, Interleukin 6, and C-Reactive Protein with the Risk of Developing Type 2 Diabetes: A Retrospective Cohort Study of Rural Thais
Table 3
Odds ratios (ORs) and 95% confidence intervals (CIs) for 2-year progression of type 2 diabetes according to baseline serum inflammatory marker levels.
Variables
Univariate analysis
Multivariate analysis
Crude OR (95% CI)
value
Adjusted OR (95% CI)
value
CRP (mg/dl)
Low level (<1.00)
1
1
High level (≥1.00)
4.20 (1.92-9.14)
<0.001
4.02 (1.77-9.12)
0.001
IL-6 (pg/ml)
1st tertile (<5.93)
1
1
2nd tertile (5.93-85.65)
1.19 (0.53-2.68)
0.679
1.08 (0.46-2.52)
0.828
3rd tertile (>85.65)
1.51 (0.69-3.34)
0.303
1.57 (0.68-3.59)
0.291
TNF-α (pg/ml)
1st tertile (<36.47)
1
1
2nd tertile (36.47-73.30)
1.41 (0.62-3.21)
0.408
1.35 (0.57-3.19)
0.489
3rd tertile (>73.30)
1.66 (0.74-3.72)
0.215
1.63 (0.70-3.79)
0.260
Abbreviations: CRP: C-reactive protein; IL-6: interleukin 6; TNF-α: tumor necrosis factor alpha. OR was adjusted for age, gender, WHR, VF, and TG.
