N¹-Methylnicotinamide Improves Hepatic Insulin Sensitivity via Activation of SIRT1 and Inhibition of FOXO1 Acetylation

Figure 6

MNAM activates Sirt1 expression and inhibits acetylation of FOXO1 in the liver of obese T2DM mice (). (a) Western blots; (b) bar graphs of acetylation of FOXO1; (c) bar graphs of SIRT1 and FOXO1. Compared with the control group, ; ^#compared with the CMNAM group, ; ^$compared with the DM group, ; ns: not significant, .

(a)

(b)

(c)