N¹-Methylnicotinamide Improves Hepatic Insulin Sensitivity via Activation of SIRT1 and Inhibition of FOXO1 Acetylation

Figure 7

MNAM regulates hepatocyte insulin sensitivity via activation of SIRT1. (a)The result of Western blots (); (b) bar graphs of acetylation of FOXO1; (c) bar graphs of SIRT1 and FOXO1; (d) glucose residual amounts; (e) real-time PCR data used to detect mRNA expression of Pepck and G-6-Pase in cells from each group; (f) bar graphs of IRS2, PI3K, AKT, and GSK3β; (g) bar graphs of p-IRS2/IRS2, p-PI3K/PI3K, p-AKT/AKT, and p-GSK3β/GSK3β. , compared with the control group; ^#, compared with the PA group; ^$, compared with the MNAM group; ns: , not significant.

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