Insulin-Attenuated Inflammatory Response of Dendritic Cells in Diabetes by Regulating RAGE-PKCβ1-IRS1-NF-κB Signal Pathway: A Study on the Anti-Inflammatory Mechanism of Insulin in Diabetes

Figure 1

Insulin therapy improved condition in DM mice. (a, b) GTT (a) and ITT (b) experiments were performed to identify the DM mice. Glucose and insulin tolerance in the DM group decreased significantly, suggesting that diabetes mellitus mouse models were successfully established. (c–e) Compared with the Sham group, the blood glucose (c) of the DM group was significantly increased, and the weight (d) was significantly decreased. Besides, expressions of TNF-α, IFN-γ, IL-6, IL-1b, and CCL2 in plasma analyzed by ELISA were significantly increased (e). However, insulin treatment reversed these. Data are expressed as ; ; , , and vs. Sham group; ^# vs. DM group. DM: diabetes mellitus; GTT: glucose tolerance test; ITT: insulin tolerance test.

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