Effects of Sodium-Glucose Cotransporter 2 Inhibition on Glucose Metabolism, Liver Function, Ascites, and Hemodynamics in a Mouse Model of Nonalcoholic Steatohepatitis and Type 2 Diabetes

Figure 2

Blood transaminase activities were very high, and there was advanced liver fibrosis in MCDD-fed mice. (a) Plasma transaminase activities before and after 2 weeks of administration of each agent. per group. Data are . ^† for the effect of diet, before the administration of each agent, by two-way ANOVA. and vs. PBS in HFD-fed mice. (b) Relative liver mass (top; per group) and triglyceride content (bottom; per group) prior to treatment (NCD-, HFD-, or HFD + MCDD-fed). Data are . and for the effect of diet by two-way ANOVA. (c) Gross appearance (top) and histopathology (H&E (middle) and Sirius Fast Red-Green (bottom) staining) of the livers of mice fed an NCD-, HFD-, or HFD + MCDD for 19 weeks. Scale bars: 5 mm (top) and 100 μm (middle and bottom). (d) Score of steatosis, inflammation, and fibrosis stage. per group. Hepatic fibrosis was exacerbated by MCDD feeding. and vs. NCD-fed mice. ^†vs. HFD-fed mice.

(a)

(b)

(c)

(d)