CCAAT/Enhancer-Binding Protein β Mediates Oxygen-Induced Retinal Neovascularization via Retinal Vascular Damage and Vascular Endothelial Growth Factor

Figure 2

Retinal vascular patterns in flat mounts after FITC-dextran perfusion at P14. (a) Staining in retinas from the control rats in room air conditions. The white box indicates the boundary of the blood vessel and shows the corresponding magnification on the right. (b) Staining in retinas from rats with OIR without any treatment. The white box indicates the boundary of the blood vessel and shows the corresponding magnification on the right. (c) Staining in retinas from rats with OIR that received intravitreal injection of control lentiviral particles. The white box indicates the boundary of the blood vessel and shows the corresponding magnification on the right. (d) Staining in retinas from rats with OIR that received intravitreal injection of C/EBP β shRNA lentiviral particles. The white box indicates the boundary of the blood vessel and shows the corresponding magnification on the right. (e–h) Image produced in Photoshop. The avascular areas are yellow. (i) Quantitative analysis of the avascular areas. versus rats in the RA group. ^## versus rats in the LV.shScrambled group.

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)

(i)