Association between Circulating B-Type Natriuretic Peptide and Diabetic Peripheral Neuropathy: A Cross-Sectional Study of a Chinese Type 2 Diabetic Population

Table 1

Circulating levels of BNP and other clinical characteristics between T2DM patients with and without DPN.

Variables	No DPN	DPN
	()	()
Male/female	65/132	27/34	0.109
Age (years)			0.014
BMI (kg/m^2)			<0.001
Diabetic duration (years)			0.170
SBP (mmHg)			0.446
DBP (mmHg)			0.615
FBG (mmol/L)			0.206
HbA1c (%)			0.068
TC (mmol/L)			0.224
TG (mmol/L)			0.087
HDL-C (mmol/L)			0.276
LDL-C (mmol/L)			0.349
Neutrophil count (10^9/L)			0.026
Lymphocyte count (10^9/L)			<0.001
NLR			<0.001
WBC (10^9/L)			0.517
PT (s)			0.249
APTT (s)			0.194
INR			0.674
Fibrinogen (g/L)			0.023
BNP (pg/mL)			0.001
ACR (mg/g)			0.004
Creatinine (μmol/L)			0.007
eGFR (mL/min/1.73 m^2)			0.002
VPT (V)			<0.001
ABI			0.028
Hypertension (, %)	112 (56.85)	39 (63.93)	0.328
CHD (, %)	27 (13.71)	13 (21.31)	0.152
Stroke (, %)	45 (22.84)	20 (32.79)	0.119
DFU (, %)	6 (3.05)	8 (13.11)	0.002
PAD (, %)	23 (11.68)	18 (29.51)	0.001
DN (, %)	66 (33.50)	36 (59.02)	<0.001
DR (, %)	21 (10.66)	13 (21.31)	0.032

Data are . SD: standard deviation; BMI: body mass index; SBP: systolic blood pressure; DBP: diastolic blood pressure; FBG: fasting blood glucose; HbA1c: glycated hemoglobin A1c; TC: total cholesterol; TG: triglyceride; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; NLR: neutrophil-to-lymphocyte ratio; WBC: white blood cell; RDW: red cell distribution width; PT: prothrombin time; APTT: activated partial thromboplastin time; INR: international normalized ratio; BNP: B-type natriuretic peptide; ACR: albumin-to-creatinine ratio; eGFR: estimated glomerular filtration rate; VPT: vibration perception threshold; ABI: ankle-brachial index; CHD: coronary heart disease; DFU: diabetic foot ulceration; PAD: peripheral arterial disease; DN: diabetic nephropathy; DR: diabetic retinopathy; DPN: diabetic peripheral neuropathy; T2DM: type 2 diabetes mellitus.