The Effects of New Selective PPARα Agonist CP775146 on Systematic Lipid Metabolism in Obese Mice and Its Potential Mechanism

Figure 2

CP775146 attenuates dyslipidemia in HFD mice. (a) Body weight, (b) liver/weight ratio, (c) serum TG level, (d) serum TC level, (e) serum LDL-c level, (f) serum HDL-c level, and (g) serum non-HDL-c level. (/group) are shown. , , and vs. chow-fed mice; , , and vs. the HFD-NC group. According to the safe dose, HFD-fed mice were divided into these groups: (1) HFD-NC group, ; (2) HFD-0.1 group (0.1 mg/kg), ; and (3) HFD-0.3 group (0.3 mg/kg), . Saline or CP775146 was given via intraperitoneal injection for 3 days.

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