Risk Factors for Cognitive Impairment in Patients with Type 2 Diabetes

Table 6

Correlations between amino acid levels (μmol/L) and cognitive impairment in T2DM patients of advanced age.

Amino Acid	NCF group ()	MCI group ()	MoCI group ()	SCI group ()		value
Ala	135.84 (111.22, 156.64)	134.51 (125.86, 153,81)	133.43 (105.13, 149.17)	126.26 (100.07, 175.67)	1.345	0.862
Arg	4.19 (2.23, 7.30)	3.04 (2.23, 4.13)	2.92 (2.05, 3.84)	1.10 (0.85, 3.29)	2.342	0.013
Asn					0.284	0.837
Asp	27.33 (18.52, 36.89)	18.74 (14.17, 22.60)	16.40 (12.80, 18.21)	14.26 (13.37, 17.08)	2.920	0.097
Cit	20.11 (17.94, 23.32)	22.17 (18.26, 25.14)	20.59 (17.70, 22.58)	16.96 (14.89, 19.18)	1.585	0.167
Orn	12.39 (10.15, 15,39)	9.30 (8.67, 11.06)	9.05 (7.53, 10.35)	10.11 (7.25, 9.48)	2.447	0.061
Gln	2.33 (7.35, 14.09)	4.93 (5.75, 6.54)	6.01 (4.59, 5.37)	9.02 (2.04, 4.11)	6.678	0.001
Lys	165.79 (130.53, 259.59)	106.48 (101.65, 115.36)	86.26 (80.31, 93.99)	40.89 (35.79, 72.03)	3.275	0.001
Met	18.87 (16.54, 24.10)	16.52 (14.85, 19.37)	16.21 (13.84, 18.16)	17.52 (14.86, 18.94)	2.179	0.061
His	50.67 (42.06, 190.74)	34.99 (32.94, 38.69)	43.58 (29.07, 37.23)	33.66 (26.58, 33.79)	3.111	0.072
Leu	160.23 (138.89, 189.05)	134.87 (109.26, 152.48)	130.26 (115.28, 146.71)	143.43 (111.91, 152.58)	1.424	0.067
Gly	172.83 (160.11, 196.85)	166.34 (147.75, 178.87)	162.65 (153.88, 176.33)	171.11 (146.03, 184.29)	2.532	0.087
Glu	213.57 (117.93, 140.35)	184.93 (101.56, 123.83)	132.12 (92.05, 128.00)	108.34 (108.98, 250.08)	4.256	0.002
Trp	45.96 (41.89, 54.74)	42.86 (35.50, 51.09)	40.58 (35.37, 47.35)	55.25 (40.61, 67.82)	2.245	0.083
Pro	608.33 (506.93, 739.37)	532.34 (481.76, 688.28)	521.25 (421.82, 586.46)	529.97 (323.26, 457.34)	5.920	0.044
Phe	36.79 (32.60, 43.96)	34.17 (28.30, 36.24)	32.01 (28.96, 36.99)	31.69 (27.87, 33.40)	6.645	0.003
Pip					4.384	0.076
Tyr					6.420	0.020
Val					1.142	0.335
Thr					2.920	0.057
Ser					2.447	0.067
Hcy					5.678	0.045
Cys					2.179	0.094
Val/Phe	4.19 (3.70, 4.55)	4.40 (3.78, 4.95)	4.28 (3.91, 4.76)	4.79 (4.50, 5.15)	3.253	0.157
Tyr/Cit	1.33 (1.08, 1.68)	1.12 (0.95, 1.34)	1.14 (0.97, 1.42)	1.47 (1.26, 1.79)	2.173	0.055
Phe/Tyr	0.75 (0.65, 0.86)	0.67 (0.63, 0.76)	0.70 (0.62, 0.81)	0.74 (0.68, 0.84)	2.179	0.258
Orn/Cit	0.57 (0.46, 0.79)	0.44 (0.41, 0.56)	0.45 (0.40, 0.52)	0.50 (0.42, 0.52)	3.119	0.051
Met/Phr	0.52 (0.46, 0.59)	0.50 (0.45, 0.56)	0.48 (0.45, 0.55)	0.57 (0.45, 0.57)	3.420	0.118
Met/Leu	0.13 (0.12, 0.14)	0.13 (0.11, 0.16)	0.12 (0.10, 0.13)	0.15 (0.11, 0.16)	1.132	0.303
Gly/Ala	1.10 (0.91, 1.35)	1.05 (0.88, 1.25)	1.13 (0.92, 1.24)	0.96 (0.88, 1.23)	2.920	0.562
Cit/Arg	5.30 (2.40, 9.06)	7.14 (5.13, 10.24)	7.09 (5.13, 10.33)	19.13 (5.52, 21.58)	1.585	0.054
Arg/Orn	0.37 (0.24, 0.44)	0.28 (0.22, 0.40)	0.32 (0.24, 0.42)	0.13 (0.11, 0.35)	2.447	0.085
Val/Phe	4.19 (3.70, 4.55)	4.40 (3.78, 4.95)	4.28 (3.91, 4.76)	4.79 (4.50, 5.15)	3.253	0.157
Tyr/Cit	1.33 (1.08, 1.68)	1.12 (0.95, 1.34)	1.14 (0.97, 1.42)	1.47 (1.26, 1.79)	2.173	0.055

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