Combination of Composite Autonomic Symptom Score 31 and Heart Rate Variability for Diagnosis of Cardiovascular Autonomic Neuropathy in People with Type 2 Diabetes

Table 4

Comparison of diagnostic value among COMPASS 31 score and HRV indices.

Variables	Cutoff	Sensitivity; (%)	Specificity; (%)	PPV; (%)	NPV; (%)	AUC	Youden’s index	Kappa; value
COMPASS 31 score	>19.5	67.4	83.3	74.4	78.1	0.816	0.51	0.52
HRV indices
SDNN (ms)	≤95	79.1	91.7	87.2	85.9	0.919	0.71	0.72
PNN50 (%)	≤1.4	58.1	86.7	75.8	74.3	0.746	0.45	0.46
RMSSD (ms)	≤16	44.2	88.3	73.1	68.8	0.648	0.33	0.34
LF (ms^2)	≤131.4	65.1	96.7	93.3	79.5	0.865	0.62	0.65
HF (ms^2)	≤183.5	83.7	61.7	61.0	84.1	0.747	0.45	0.43
LF/HF ratio	≤0.86	48.8	88.3	75.0	70.7	0.699	0.37	0.39
Combined model	/	90.7	86.7	83.0	92.9	0.958	0.77	0.75

Combined model: the combination of COMPASS 31 score, SDNN, and LF. COMPASS 31: Composite Autonomic Symptom Score 31; HRV: heart rate variability; SDNN: the standard deviation of the NN intervals; PNN50: the percentage of adjacent NN intervals with a difference greater than 50 ms; RMSSD: the root mean square differences of successive NN intervals; LF: low-frequency power; HF: high-frequency power.