Simultaneous Pancreas Kidney Transplantation Improves Cardiovascular Autonomic Neuropathy with Improved Valsalva Ratio as the Most Precocious Test
Table 1
Paired tests for the baseline and post-SPK follow-up characteristics in SPK recipients.
Parameter
Baseline
Follow-up
3 years
5 years
7 years
10 years
42
31
16
7
4
BMI (kg/m2)
23.2 (21.9-25.5)
23.2 (20.9-25.7)
23.5 (22.5-26.5)
24.5 (22.2-26.1)
22.15(21.7-23.1)
Hemoglobin A1c (%)
7.8 (7.0-9.1)
5.5 (5.3-5.9)†
5.4 (5.1-5.5)†
5.7(5.1-5.9)¤
5.7 (5.1-5.9)
Basal glycemia (mg/dL)
168.5 (125.7-237.7)
86.0 (80.0-96.0)†
85.5 (80.0-94.7)¤
86.0 (75.0-98.0)†
83.0 (76.2-109.2)
C-peptide (ng/mL)
0.1 (0.1-0.4)
2.4 (1.8-3.2)†
2.2 (1.6-2.6)†
1.7 (1.0-2.1)#
1.6 (0.6-2.9)
S-creatinine (mg/dL)
7.1 (5.6-8.1)
1.1 (1.0-1.4)†
1.1 (1.0-1.3)†
0.9 (0.8-1.2)#
0.9 (0.9-1.0)#
Urea (mg/dL)
103.0 (84.0-138.0)
55.5 (46.5-63.2)†
49.0 (44.0-61.0)†
45.0 (39.0-68.0)†
39.0 (38.0-45.2)#
eGFR (mL/min/1.73m2)
11.5 (9.0-60.0)
72.0 (57.2-84.2)†
70.0 (53.5-85.5)†
85.0 (57.0-108.0)†
89.0 (75.2-99.0)†
Cholesterol (mg/dL)
156.5 (124.2-181.7)
164.0 (151.0-175.0)
178.0 (161.2-189.0)
158.0 (146.0-174.0)
169.5 (145.0-178.2)
HDL-C (mg/dL)
43.0 (34.5-59.5)
56.5 (45.2-70.0)
68.0 (58.5-75.7)
64.0 (56.0-69.0)
61.0 (61.0-.63.0)
LDL-C (mg/dL)
80.0 (51.0-97.5)
93.0 (84.0-104.0)
93.5 (79.5-103.7)
84.0 (76.0-92.0)
105.0 (78.0-106.0)
Triglycerides (mg/dL)
113.5 (86.2-167.0)
74.5 (55.0-87.7)†
67.0 (55.0-81.0)†
57.0 (46.0-71.0)
68.5 (55.5-76.2)
Systolic blood pressure (mmHg)
141.0 (130.0-156.0)
120.0 (113.7-130.0)†
128.0 (115.0-131.0)#
128.0 (105.2-130.0)
127.5 (113.7-139.7)
Diastolic blood pressure (mmHg)
76.0 (70.0-81.0)
70.0 (65.0-75.0)¤
70.0 (70.0-77.0)
71.0 (52.7-80.2)
75.5 (65.2-79.0)
Patients with hypolipemiant treatment
26 (61.9%)
8 (19.0%)#
5 (11,9%)#
1 (2.4%)nd
1 (2.4%)nd
Patients with antihypertensive treatment
40 (95.2%)
16 (38.1%)#
10 (23.8%)#
4 (9.5%)†
3 (7.1%)†
Patients with beta-blockers treatment
13 (30.9%)
3 (9.7%)†
1 (6.25%)†
0 (0%)†
0 (0%)†
Patients with diagnosis of CAN/patient with CARTs performed
30/31 (96.8%)
16/16 (100%)
11/13 (84.6%)
5/6 (83.3%)
2/3 (66.7%)
SPK: simultaneous pancreas and kidney transplantation; BMI: body mass index; eGFR: estimated Glomerular Filtration Rate; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; CAN: cardiovascular autonomic neuropathy. †, patients at 3, 5, 7, or 10 years after SPK vs baseline. #, patients at 3, 5, 7, or 10 years after SPK vs baseline. ¤, patients at 3, 5, 7, or 10 years after SPK vs baseline. nd: test not done.
