Research Article
The Usefulness of Genotyping of Celiac Disease-Specific HLA among Children with Type 1 Diabetes in Various Clinical Situations
Table 1
Characteristic of the studied groups and the results of the genetic tests.
| | Group I: 92 (63%) | Group II: 30 (21%) | Group III: 23 (16%) | Groups II and III: 53 (37%) | value group I (T1D) vs. groups II and III (CD) | value group II vs. group III | value (all groups) |
| | Female ( (%)) | 32 (35%) | 16 (53%) | 8 (35%) | 24 (45%) | NS | NS | NS | | ( (%)) | 56 (61%) | 21 (70%) | 15 (65%) | 36 (68%) | NS | NS | NS | | ( (%)) | 65 (71%) | 24 (80%) | 16 (70%) | 40 (75%) | NS | NS | NS | | (n (%)) | 15 (16%) | 4 (13%) | 3 (13%) | 7 (13%) | NS | NS | NS | | ( (%)) | 53 (58%) | 18 (60%) | 17 (74%) | 35 (66%) | NS | NS | NS | | ( (%)) | 52 (57%) | 4 (13%) | 9 (39%) | 13 (25%) | 0.001 | 0.031 | 0.001 | | Age at T1D diagnosis (years) (Me (IQR)) | 9.99 (5.32–13.52) | 5.19 (2.38–9.10) | 5.60 (3.16–7.88) | 5.41 (2.84–8.71) | 0.001 | NS | 0.001 | | Age at CD diagnosis (years) (Me (IQR)) | | 7.30 (5.10–11.10) | 6.96 (4.80–11.53) | 7.23 (5.04–11.32) | — | NS | NS | | TTG (U/ml) | 4.8 (3.3–7.6) | 160.0 (71.9–704.0) | 73.6 (51.0–118.0) | 109.6 (60.0–321.0) | 0.001 | 0.004 | 0.001 | | ZnT8 (U/ml) | 221.0 (29.8–539.9) | 110.0 (4.9–529.0) | 166.3 (15.3–310.7) | 120.0 (5.1–507.4) | NS | NS | NS | | IA2 (U/ml) | 216.0 (3.9–722.0) | 21.7 (7.0–922.0) | 185.9 (1.6–666.1) | 96.6 (3.8–801.1) | NS | NS | NS | | GAD (U/ml) | 83.0 (6.7–560.0) | 51.9 (5–375.0) | 42.7 (13.3–402.6) | 49.0 (8.6–395.2) | NS | NS | NS |
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