Genetic and Biological Effects of ICAM-1 E469K Polymorphism in Diabetic Kidney Disease

Figure 1

Genotype distribution of the ICAM1 E469K polymorphism and circulating ICAM-1 levels in type 1 and type 2 diabetes with or without diabetic kidney disease. Genotype distribution patterns (top) showed a high frequency of heterozygous genotypes in type 1 diabetes (T1D) subjects with or without diabetic kidney disease (DKD) (Figure 1(a)) and type 2 diabetes (T2D) patients with or without DKD (Figure 1(b)). According to the genotypes, serum/plasma ICAM-1 levels were analyzed (bottom). In T1D subjects with DKD, the heterozygous ICAM1 E469K carriers had higher circulating ICAM-1 levels than what in homozygous E469E and K469K carriers (, adjusted for age and sex) (Figure 1(c)). The similar finding was found in T2D patients with DKD (, adjusted for age and sex) (Figure 1(d)). Data were replicated and modified from Ma et al. 2006 and Abu Seman et al. 2013.

(a)

(b)

(c)

(d)