Genetic and Biological Effects of ICAM-1 E469K Polymorphism in Diabetic Kidney Disease

Figure 2

Structural context of the ICAM1 E469K polymorphism. The structures are shown as ribbon cartoon diagrams. (a) Model of the dimeric ICAM-1 ectodomain bound to the αI domain of integrin LFA-1 reconstructed by combining two crystal structures. Glu-469 in domain 5 is shown with its sidechain atoms as spheres. The Mg²⁺ ion at the center of the LFA-1/ICAM-1 binding site is shown as a silver sphere. (b) Detailed view of the region boxed in (a). Sidechains of Glu-469 and nearby residues are shown in stick representation, and Glu-469 is emphasized with thicker stick. The boundary between the G β-strand in D4 that continues into the A β-strand in D5 is shown with a dotted line in the cyan ICAM-1 monomer.

(a)

(b)